Clinical, Laboratory and Virological Characteristics of Patients with Positive Hepatitis B Surface Antigen

Background and Aim: Globally, Hepatitis B virus (HBV) infection is a major health issue contributing to various diseases such as hepatocellular carcinoma (HCC) liver cirrhosis. Virus replication complex interaction with host immune system response causes dynamic interplay leading HBV infection. In developing countries, plays significant role in higher rates of morbidities mortalities. The present study aimed assess the clinical, laboratory, virological characteristics patients positive surface antigen. Methodology: This cross-sectional was carried out on 182 antigen (HBsAg) department Medicine, Social Security Hospital, Multan Road Lahore from April 2021 March 2022. All HBsAg negative hepatitis C were enrolled. Patients history chronic disease, acute infection, antiviral therapy excluded. underwent CBC, function tests, clinical evaluation, abdominal ultrasonography examination, serological marker’s assessment, transmission risk factors, HBV-DNA quantitative detection. SPSS version 25 used for data analysis. Results: Out infected patients, there 162 (89%) males 20 (11%) females. overall mean age 38.6 ± 8.6 years. most prevalent complaint common findings arthralgia hepatomegaly reported incidence 32 (17.6%) 16 (8.8%) respectively. Based imaging results, normal liver, coarse splenomegaly, cirrhosis found 81.3% (n=148), 12.6% (n=23), 5.9% (n=11), 6.6% (n=12) laboratory alanine aminotransferase, aspartate reduced serum albumin, low platelet count 76.9%, 84.8%, 4.9%, 10.2% Regarding characteristics, had no differences. Conclusion: that patient’s manifestations fatigue, bleeding gums, pain fatigue. Majority tests ultrasonographic examination. Most comparisons made between positive, substantial variations characteristics. Keywords: antigen, Virological